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Generation of Stable CD4+and CD8+T Cell Lines from Patients Immunized withrasOncogene-Derived Peptides Reflecting Codon 12 Mutations

✍ Scribed by Scott I. Abrams; Samir N. Khleif; Elke S. Bergmann-Leitner; Judith A. Kantor; Yoomie Chung; J.Michael Hamilton; Jeffrey Schlom

Book ID
112239869
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
243 KB
Volume
182
Category
Article
ISSN
0008-8749

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✍ Marianne K. Gjertsen; Jens BjΓΈrheim; Ingvil Saeterdal; June Myklebust; Gustav Ga πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 French βš– 119 KB πŸ‘ 1 views

Mutant p21-ras proteins contain sequences that distinguish them from normal ras, and represent unique epitopes for T-cell recognition of antigen-bearing tumour cells. Here, we examined the capacity of CD4 Ψ‰ and CD8 Ψ‰ T cells, generated simultaneously by mutant-ras-peptide vaccination of a pancreatic