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Generation of Reactive Species and Fate of Thiols during Peroxidase-Catalyzed Metabolic Activation of Aromatic Amines and Phenols

✍ Scribed by David Ross and Peter Moldeus

Book ID
124276021
Publisher
Environmental Health Information Service
Year
1985
Tongue
English
Weight
259 KB
Volume
64
Category
Article
ISSN
0091-6765

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## Abstract Food‐derived heterocyclic aromatic amines (HCAs) have proved to be carcinogenic in both rodents and nonhuman primates. Two different metabolic pathways are suggested for the metabolic activation of HCA. The hepatic pathway proceeds via a two‐step process involving __N__‐hydroxylation by