✦ LIBER ✦
Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries
✍ Scribed by Bryan Klekota; Mark H. Hammond; Benjamin L. Miller
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 282 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
We describe a general method for the selection of compounds from self-assembled libraries which employs an immobilized receptor (i.e., an affinity reagent) to effect the selection. Using commercially available oligo d(A.T) DNA-cellulose resin, a set of three setereoisomeric coordination complexes are identified as DNA binding compounds from an equilibrating, self-assembled library of 36 bis(salicylaldiminato)-zinc coordination complexes.