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Generation of neutralizing antibody to the reverse transcriptase of human immunodeficiency virus type 1 by immunizing of mice with an infectious vaccinia virus recombinant

✍ Scribed by Joe Chiba; Masakazu Nakano; Yoshinori Suzuki; Kazumi Aoyama; Hiroyoshi Ohba; Toshiaki Kobayashi; Atsushi Yasuda; Asato Kojima; Takeshi Kurata


Book ID
114051832
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
107 KB
Volume
207
Category
Article
ISSN
0022-1759

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Inhibitory antibodies to the reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) can be used to block the life cycle of the virus. We have isolated five different human single chain Fv (ScFv) antibodies specific for HIV-1 RT from an antibody phage display library. Three of thes