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Generation of neural crest progenitor cells from human induced pluripotent stem cells by a simple method

✍ Scribed by Shigeki Ohta; Aya Misawa; Hironobu Okuno; Kimiko Fukuda; Wado Akamatsu; Yutaka Kawakami; Hideyuki Okano


Book ID
116778921
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
111 KB
Volume
71
Category
Article
ISSN
0168-0102

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## Abstract The neural crest (NC) is a transient population of multipotent progenitors arising at the lateral edge of the neural plate in vertebrate embryos, which then migrate throughout the body to generate diverse array of tissues such as the peripheral nervous system, skin melanocytes, and cran

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The team of Liu et al. generated endoderm-derived human induced pluripotent stem (iPS) cells from primary hepatocytes. 1 However, they generated human iPS cells by using viral transgenes. 1 Clinical applications of human iPS cells require avoiding viral transgenes. On the other hand, the reprogrammi