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Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity

✍ Scribed by Motohiro Horiuchi; Ayako Karino; Hidefumi Furuoka; Naotaka Ishiguro; Kumiko Kimura; Morikazu Shinagawa


Book ID
113947951
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
699 KB
Volume
394
Category
Article
ISSN
0042-6822

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Background: Human monoclonal antibodies (mAbs) generated as a result of the immune response are likely to be the most effective therapeutic antibodies, particularly in the case of infectious diseases against which the immune response is protective. Human cytomegalovirus (HCMV) is an ubiquitous oppo