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Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

✍ Scribed by Beatrice Thurner; Claudia Röder; Detlef Dieckmann; Marion Heuer; Monika Kruse; Anke Glaser; Petra Keikavoussi; Eckhart Kämpgen; Armin Bender; Gerold Schuler


Book ID
114052124
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
939 KB
Volume
223
Category
Article
ISSN
0022-1759

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Closed system generation of dendritic ce
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Dendritic cells (DC) used for clinical trials should be processed on a large scale conforming to current good manufacturing practice (cGMP) guidelines. The aim of this study was to develop a protocol for clinical grade generation of immature DC in a closed-system. Aphereses were performed with the C