✦ LIBER ✦
Generation of influenza A virus from cloned cDNAs — historical perspective and outlook for the new millenium
✍ Scribed by Gabriele Neumann; Yoshihiro Kawaoka
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 232 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1052-9276
- DOI
- 10.1002/rmv.332
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Influenza virus reverse genetics has reached a level of sophistication where one can confidently generate virus entirely from cloned DNAs. The new systems makes it feasible to study the molecular mechanisms of virus replication and pathogenicity, as well as to generate attenuated live virus vaccines, gene delivery vehicles, and possibly other RNA viruses from cloned cDNAs. During the next decade, one can anticipate the translation of influenza virus reverse genetics into biomedically relevant advances. Copyright © 2002 John Wiley & Sons, Ltd.