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Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia

✍ Scribed by Nabarro, S; Thrasher, A J; Kempski, H; Amrolia, P; Anderson, J


Book ID
110055590
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
116 KB
Volume
17
Category
Article
ISSN
0887-6924

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## Abstract Chronic myelogenous leukemia is caused by the acquisition of the reciprocal (9;22)(q34;q11) chromosomal translocation in hematopoietic stem cells. The fusion protein showed higher and aberrant tyrosine kinase activity. The inhibition of the tyrosine kinase activity of the protein repres