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Generation of free radicals from dihydropyranzines with DNA strand-breakage activity

✍ Scribed by Tadatoshi Yamaguchi; Shigenobu Matsumoto; Kenji Watanabe

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
135 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

ESR spin-trapping techniques revealed that free radical species were generated in a buffer solution (pH7.1) of compounds (1 ~ 5) having a dihydropyrazine skeleton. Oxygen radicals and several carbon-centered radicals were detected as adducts of spin traps: DMPO and DBNBS. Secondary and tertiary radicals trapped were assigned to the carbon-centered radical structures.

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