Generation of Chromosome Painting Probes from Single Chromosomes by Laser Microdissection and Linker-Adaptor PCR

Maternal balanced translocation leading

Maternal balanced translocation leading to partial duplication of 4q and partial deletion of 1p in a son: Cytogenetic and FISH studies using band-specific painting probes generated by chromosome microdissection

✍ Chen, Zhong; Grebe, Theresa A.; Guan, Xin-Yuan; Notohamiprodjo, Mathilda; Nuttin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB 👁 3 views

A 9-month-old boy with pre-and post-natal growth retardation, microcephaly, plagiocephaly, and several minor anomalies had the initial karyotype: 46,XY,der(1)t(1;?) (p36.1;?). Further analysis showed that the der(1) was derived from an unfavorable segregation of a maternal complex chromosome rearran