Generation of B lymphoma cell lines from knockout mice by transformation in vivo with an Eμ-myc transgene

Upregulation of endogenous p53 and induc

Upregulation of endogenous p53 and induction of in vivo apoptosis in B-lineage lymphomas of Eμ-myc transgenic mice by deregulated c-myc transgene

✍ V. S. Prasad; Richard E. LaFond; Ming Zhou; Karen A. Jacobsen; Dennis G. Osmond; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 483 KB

Eµ-myc transgenic mice carry a constitutively overexpressed c-myc oncogene and develop B-lineage lymphomas. Previous studies have shown that c-myc overexpression can lead to in vitro apoptosis. Here, we investigated the in vivo effects of altered c-myc expression on cell proliferation versus death i