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Generation of allo-restricted cytotoxic T lymphocytes against malignant glioma by artificial antigen-presenting cells

✍ Scribed by Xiao-ling Lu; Xiao-bing Jiang; Ru-en Liu; Fang-cheng Zhang; Hong-yang Zhao


Book ID
116334500
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
284 KB
Volume
256
Category
Article
ISSN
0304-3835

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## Abstract Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHC‐I) molecules on the surface of target cells. Optimal induction of CD8^+^ CTL depends on the amount of relevant peptide/MHC‐I complexes and the presence of co‐stimulatory