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Generation of Active-Form of Matrix Metalloproteinase-9 Induced by Hydroxyl Radical: A Possible In Vitro Model for Oxidative Stress-Induced Degradation of Cartilage Matrix in the TMJ

✍ Scribed by Eiro Kubota


Book ID
113737827
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
41 KB
Volume
65
Category
Article
ISSN
1531-5053

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti