Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration

Up-regulation of MUC1 in mammary tumors

Up-regulation of MUC1 in mammary tumors generated in a double-transgenic mouse expressing human MUC1 cDNA, under the control of 1.4-kb 5′ MUC1 promoter sequence and the middle T oncogene, expressed from the MMTV promoter

✍ Rosalind A. Graham; Joanna R. Morris; Edward P. Cohen; Joyce Taylor-Papadimitrio 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 673 KB

In this study we examined the regulation of expression of the human MUC1 gene in vivo, by developing MUC1 transgenic mice. The data showed that epithelial-specific expression of MUC1 can be directed by just 1.4 kb of 5' flanking sequence using MUC1 cDNA as a reporter gene in vivo. Furthermore, high