Generation of a recombinant Sendai virus that is selectively activated and lyses human tumor cells expressing matrix metalloproteinases

Expression of membrane type 1 matrix met

Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization

✍ Nor Eddine Sounni; Eugenia N. Baramova; Carine Munaut; Erik Maquoi; Francis Fran 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 778 KB

## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t