Generation and characterization of human monoclonal single chain variable fragments (scFvs) against envelope third variable region (V3) of HIV-1 clade C

Generation and characterization of a hum

Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast

✍ Alessandra Mallano; Silvia Zamboni; Giulia Carpinelli; Filippo Santoro; Michela 📂 Article 📅 2008 🏛 BioMed Central 🌐 English ⚖ 665 KB

## Background The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to model gene or antibody – directed enzyme-prodrug