Generation and carbonyl addition reactions of Z-dilithiohex-3-ene-1,5-diyne

✍ Scribed by Samuel J. Danishefsky; Dennis S. Yamashita; Nathan B. Mantlo

• Book ID: 104216691
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 256 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)80579-1

✦ Synopsis

The reaction of the title dilithio salt with carbonyl compounds leads to products bearing substructures found in recently discovered enediyne antibiotics. The his condensation product with benzaldehyde undergoes a novel cycloaromatization reaction.

The recent recognition of the role of neocarzinostatin chromophore A, 1.2 followed by the isolation of