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Generalized Proteochemometric Model of Multiple Cytochrome P450 Enzymes and Their Inhibitors

✍ Scribed by Kontijevskis, Aleksejs; Komorowski, Jan; Wikberg, Jarl E. S.

Book ID
118012233
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
411 KB
Volume
48
Category
Article
ISSN
0095-2338

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## Abstract The cytochrome P450 enzyme cytochrome P450 3A4 (CYP3A4) controls the metabolism of about 60% of all drugs, and its inhibition may dramatically affect drug safety. Modulation of cytochrome P450 activity has been observed by constituents of fruit extracts including several flavonoids. The