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General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes

✍ Scribed by Patrick Casara; Karin Jund; Philippe Bey

Book ID: 118549927
Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 220 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)90068-1

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We recently demonstrated that 1-carboxy-lyases can be irreversibly inhibited by the a-difluoromethyl derivatives of their parent a-amino acid substrates or by the a-acetylenic analogues of their parent amine products 192 . The mechanistic rationalization of the inactivation by the a-acetylenic amine