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General synthesis of 4-isoxazolecarboxylic acids

✍ Scribed by Stork, Gilbert.; McMurry, John E.


Book ID
120496617
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
255 KB
Volume
89
Category
Article
ISSN
0002-7863

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A series of 5-aminomethinimino-3-methyl-4-isoxazolecarboxylic acid phenylamides 4 has been prepared by condensation of 5amino-3-methyl-4-isoxazolecarboxylic acid phenylamides 1 with trichloroacetic aldehyde. Alcoholysis of trichloro derivatives 2 gave 5-alkoxymethine derivatives 3 which, on reaction