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General Strategy for the Asymmetric Synthesis of the Picrotoxanes

✍ Scribed by Trost, Barry M.; Krische, Michael J.


Book ID
127235881
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
189 KB
Volume
118
Category
Article
ISSN
0002-7863

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A general methodology for the stereoselective synthesis of 1-deoxymannojirimycin and its three other stereoisomers is described. The achiral olefin 6 was converted through the common olefin intermediate 12 to the target compounds in a highly stereocontrolled manner. The regioselective asymmetric ami