General solution for diffusion-controlled dissolution of spherical particles. 2. Evaluation of experimental data
✍ Scribed by Jianzhuo Wang; Douglas R. Flanagan
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 221 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
Our general particle dissolution model uni®ed three traditional particle dissolution models and predicted that dissolution rates depend on surface curvature. Spherical benzocaine particles were prepared with a hot-melt dispersion method and physicochemically characterized. Their dissolution behavior was studied to evaluate the general dissolution model. A ¯ow-through dissolution test system was used which employed an HPLC pump, an HPLC UV detector, a cylindrical-shaped dissolution cell, and a data collection system. Single benzocaine particle dissolution pro®les were determined at ambient temperature (22±238C) in water at a constant ¯ow rate. Dissolution rate normalized by surface area was found to be particle radius-dependent and ®tted well by the general particle dissolution model with a diffusion layer thickness of 110 mm and benzocaine diffusion coef®cient of 1.4 Â 10 À5 cm 2 /s. Analysis of literature particle dissolution data also supported this general model. Our general model accounts for literature reports of apparent diffusion layer thicknesses being smaller for small particles compared with large particles. This study supports the applicability of the general particle dissolution model for a ¯ow-through dissolution test system. ß 2002