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General Methodology for the Preparation of 2,5-Disubstituted-1,3-oxazoles

โœ Scribed by Williams, David R.; Fu, Liangfeng


Book ID
120014091
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
209 KB
Volume
12
Category
Article
ISSN
1523-7060

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A Highly Regioselective Preparation of 4
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## Abstract A facile highly regioselective process is described for the formation of 4โ€chloromethylโ€1,3โ€oxazoles from 1,3โ€oxazole __N__โ€oxide/HCl salts. An explanation is presented for the high regioselectivity in deoxygenationโ€chlorination using POCl~3~ with HCl salts compared to the corresponding