General approach leading to the development of imidazoquinoline and imidazopyrimidine benzodiazepine receptor ligands
✍ Scribed by Dr. W. Roger Tully; Colin R. Gardner; Robert Westwood
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 588 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract In this study, we evaluated the applicability of ligand‐based and structure‐based models to quantitative affinity predictions and virtual screenings for ligands of the β~2~‐adrenergic receptor, a G protein‐coupled receptor (GPCR). We also devised and evaluated a number of consensus mode
Based on the amino acid sequence deduced from the cloned human peripheral benzodiazepine receptor (PBR) gene, monoclonal antibody (Mab 8D7) was produced against the C-terminal fragment of the receptor. Immunoblot experiments, performed against purifiied PBR, indicated that the antipeptide antibody r
## Abstract Histamine H~1~ antagonists or “antihistamines” are one of the most prescribed drug families in Western countries. They exert their effect by binding to the histamine H~1~ receptor, a receptor belonging to the class of rhodopsin‐like G protein‐coupled receptors (GPCRs). In this review, t