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General acid catalysis by the hepatitis delta virus ribozyme

✍ Scribed by Das, Subha R; Piccirilli, Joseph A

Book ID: 109914010
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 443 KB
Volume: 1
Category: Article
ISSN: 1552-4450
DOI: 10.1038/nchembio703

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## Abstract The self‐cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal