GENEHUNTER: Application to analysis of bipolar pedigrees and some extensions
β Scribed by Hongzhe Li; Daniel J. Schaid
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 50 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0741-0395
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β¦ Synopsis
A newly developed nonparametric multipoint linkage analysis (NPL) by
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The problem of linkage analysis of disorders with multiple possible phenotypes (diagnostic spectrum) is considered. A modification is proposed to Ott's [1994] method of down-weighting the contribution of broader diagnoses by reducing penetrance ratios for affected cases. A "robust weighting" strateg