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Gene transfer to blood vessels: a research tool and potential therapy

✍ Scribed by Donald D Heistad

Book ID
117600563
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
197 KB
Volume
14
Category
Article
ISSN
0895-7061

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The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5-fluorocytosine (5-FC) to the lethal 5-fluorouracil (5-Fu) and so provides a useful system for selective killing of gene-modified mammalian tumor cells. Cloning of the CD gene from Escherichiu coli and expression in human tumo