✦ LIBER ✦

Gene transfer therapy for neurodegenerative disorders

✍ Scribed by Andrew Feigin; David Eidelberg

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 120 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21423

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✦ Synopsis

Abstract

Recent advances in gene transfer technology have led to promising new therapies for neurodegenerative disorders. This article will review methods of gene transfer therapy and applications of these techniques to both genetic and sporadic neurodegenerative illnesses. The article will focus on Parkinson's disease, Huntington's disease, and Alzheimer's disease. Several promising gene therapy approaches to these diseases are being pursued both in animal models and in early human trials. Initial safety–tolerability results from these trials appear promising. It is therefore likely that the number of human trials of gene therapy for neurodegenerative disorders will increase over the coming years. © 2007 Movement Disorder Society

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