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Gene transfer of CD40-ligand to dendritic cells stimulates interferon-γ production to induce growth arrest and apoptosis of tumor cells

✍ Scribed by Tomihara, K; Kato, K; Masuta, Y; Nakamura, K; Uchida, H; Sasaki, K; Tanaka, T; Huang, J; Hiratsuka, H; Hamada, H


Book ID
110040100
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
513 KB
Volume
15
Category
Article
ISSN
0969-7128

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Gene transfer of the CD40-ligand to huma
✍ Kei Tomihara; Kazunori Kato; Yukari Masuta; Kiminori Nakamura; Toshihiro Tanaka; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 461 KB

## Abstract The CD40‐ligand (CD40L) is a key molecule for the activation of dendritic cells (DCs), followed by the induction of DC maturation and cytokine production. Here we found that DC infected with adenovirus vector encoding human CD40L (CD40L‐DC) displayed significantly higher levels of immun