Gene transcripts in the tumour suppressor region of chromosome 3 (3p21)
β Scribed by Wail Al Sarakbi; W. Sasi; W. Jiang; T. Roberts; R. Newbold; K. Mokbel
- Book ID
- 116443724
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 42 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0748-7983
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## Abstract Chromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth __in vivo__ by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was
## Abstract Loss of heterozygosity (LOH) on chromosome 3p is a common event in cervical cancer and typically occurs in a dispersed pattern involving several loci. This implies that more than one resident tumorβsuppressor gene is involved in the genesis of these tumors; however, specific targets rem
## Abstract Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors. The __BLU__ gene, located at 3p21.3, has recently been identified as a