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Gene Therapy with Brain-Derived Neurotrophic Factor As a Protection: Retinal Ganglion Cells in a Rat Glaucoma Model

✍ Scribed by Martin, Keith R. G. ;Quigley, Harry A. ;Zack, Donald J. ;Levkovitch-Verbin, Hana ;Kielczewski, Jennifer ;Valenta, Danielle ;Baumrind, Lisa ;Pease, Mary Ellen ;Klein, Ronald L. ;Hauswirth, William W.

Book ID
124079526
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Year
2003
Weight
513 KB
Volume
44
Category
Article
ISSN
1552-5783

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✍ Yan, Qiao ;Wang, Jue ;Matheson, Christine R. ;Urich, Janal L. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 842 KB

Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli