Gene therapy: The first two decades and
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Terence R. Flotte
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Article
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2007
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John Wiley and Sons
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English
β 236 KB
## Abstract The concept of gene therapy was envisioned soon after the emergence of restriction endonucleases and subcloning of mammalian genes in phage and plasmids. Over the ensuing decades, vectors were developed, including nonviral methods, integrating virus vectors (gammaretrovirus and lentivir