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Gene Therapy Progress and Prospects: Development of improved lentiviral and retroviral vectors – design, biosafety, and production

✍ Scribed by Sinn, P L; Sauter, S L; McCray, P B

Book ID: 120994725
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 148 KB
Volume: 12
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3302570

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## Abstract The production of gene therapy retroviral vectors presents many difficulties, mainly due to vector instability and low cell productivities hampering the attainment of high titers of infectious viral vectors. The objective of this work is to increase the production titers of retroviral v