Gene Therapy of Autoimmune Disease (Medical Intelligence Unit)

✍ Scribed by Gerald J Prud'homme

• Year: 2005
• Tongue: English
• Leaves: 149
• Edition: 1
• Category: Library

✦ Synopsis

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

✦ Table of Contents

Cover Page......Page 1
Title Page......Page 2
ISBN: 0306479915......Page 3
CONTENTS......Page 5
CONTRIBUTORS......Page 7
PREFACE......Page 9
CHAPTER 1 Gene Therapy Approaches for Autoimmune Diseases of the Central Nervous System and Other Tissues......Page 11
CHAPTER 2 Gene Therapeutics in Autoimmune Diabetes......Page 27
CHAPTER 3 Immunogene Therapy with Nonviral Vectors......Page 53
CHAPTER 4 Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease......Page 81
CHAPTER 5 Therapeutic Gene Transfer for Rheumatoid Arthritis......Page 99
CHAPTER 6 Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers......Page 111
CHAPTER 7 DNA Vaccination against Autoimmune Diseases......Page 122
Index......Page 147
Back Cover Page......Page 149