Gene Therapy in Inflammatory Diseases

✍ Scribed by Christopher H. Evans, Paul D. Robbins (auth.), Prof. Christopher H. Evans, Prof. Paul D. Robbins (eds.)

• Publisher: Birkhäuser Basel
• Year: 2000
• Tongue: English
• Leaves: 263
• Series: Progress in Inflammation Research
• Edition: 1
• Category: Library

✦ Synopsis

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

✦ Table of Contents

Front Matter....Pages i-xii
Gene therapy for inflammatory diseases — basic concepts....Pages 1-11
Gene therapy for rheumatoid arthritis: preclinical studies....Pages 13-34
Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model....Pages 35-51
Gene therapy for rheumatoid arthritis: clinical studies....Pages 53-63
Cytokine gene therapy of allergic airways inflammation....Pages 65-81
Gene therapy for inflammatory diseases of the salivary glands....Pages 83-93
Gene therapy for management of lupus: Correction of Fas and Fas ligand-induced apoptosis in murine disease — therapeutic rationale and strategies....Pages 95-117
Gene therapy for multiple sclerosis....Pages 119-131
Gene therapy for type I diabetes mellitus....Pages 133-162
Gene transfer to facilitate transplantation....Pages 163-204
DNA vaccination as an anti-inflammatory strategy....Pages 205-229
Naked DNA as a gene delivery vehicle in inflammatory diseases....Pages 231-239
Animal models of arthritis generated by gene transfer....Pages 241-255
Back Matter....Pages 256-260

✦ Subjects

Surgical Orthopedics; Human Genetics; Molecular Medicine; Rheumatology