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Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene

โœ Scribed by Rosa F. Hwang; E.Maria Gordon; W.French Anderson; Dilip Parekh


Book ID
117221033
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
253 KB
Volume
124
Category
Article
ISSN
0039-6060

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Alteration of the wild-type (wt) p53 gene by mutation, deletion or re-arrangement is a major factor in the development of human colon cancer. Recent studies have demonstrated that p53 might be an essential component of the apoptotic pathway triggered by DNA-damaging stimuli such as chemotherapeutic