## Abstract To date, over 1340 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. In 1997 we set up a database to bring together global information on gene therapy clinical trials as comprehensively as possible. The data are compiled and regularly update
Gene therapy clinical trials worldwide to 2012 - an update
โ Scribed by Ginn, Samantha L.; Alexander, Ian E.; Edelstein, Michael L.; Abedi, Mohammad R.; Wixon, Jo
- Book ID
- 120539509
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 855 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1099-498X
- DOI
- 10.1002/jgm.2698
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## Abstract In 1989, Rosenberg __et al.__ performed the first human gene therapy trial when they used a retrovirus to introduce the gene coding for resistance to neomycin into human tumorโinfiltrating lymphocytes before infusing them into five patients with advanced melanoma. This study demonstrate
Part I\*: Countries, Diseases, Clinical trial phases, Routes of administration ## Countries Countries where clinical trials are being performed or have been approved Gene therapy trials have now been initiated on all ยฎve continents but the large majority of trials are being performed in the USA
Part 2\*: Gene Delivery Systems Used and Genes Transferred Delivery systems Gene delivery systems are based either on physicochemical methods or on biological methods (or a combination of the two). Gene Delivery systems used in humans to date are: Physico-chemical methods Biological methods Gene gun