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Gene therapy-based approaches to the treatment of cancer: Development of targetable retroviral vectors

โœ Scribed by Dougherty, Graeme J.; Peters, Carrie E.; Dougherty, Shona T.; McBride, William H.; Chaplin, David J.


Book ID
123136741
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
641 KB
Volume
17
Category
Article
ISSN
0955-3886

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## Abstract ## Background We have previously described the generation of reconstituting retroviral (ReCon) vectors designed for cancer gene therapy using cytotoxic gene products. The unique vector structure with a promoter physically separated from the transgene allows generation of stable virus p