✦ LIBER ✦

Gene therapy and the skin

✍ Scribed by Hengge, U.R. ;Bardenheuer, W.

Book ID: 101454043
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 107 KB
Volume: 131C
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.c.30038

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Significant progress has been made during the past decade in corrective gene therapy of the skin. This includes advances in vector technology, targeted gene expression, gene replacement, gene correction, and the availability of appropriate animal models for a variety of candidate diseases. While non‐viral integration of large genes such as essential basement membrane proteins has been mastered, new challenges such as the control of immune responses lie ahead of the research community. Among the first skin diseases, patients with junctional epidermolysis bullosa (JEB) and xeroderma pigmentosum (XP) will enter clinical trials. © 2004 Wiley‐Liss, Inc.

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