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Gene therapy: a rocky start to the new millennium

✍ Scribed by Kathryn Senior

Book ID
114382536
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
21 KB
Volume
6
Category
Article
ISSN
1357-4310

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We eliminated type beta transforming growth factor (TGF-beta) signaling by adenovirus-mediated local expression of a dominant-negative type II TGF-beta receptor (AdCATbeta-TR) in the liver of rats treated with dimethylnitrosamine, a model of persistent liver fibrosis. In rats that received a single