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Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview

✍ Scribed by Zinnia P. Parra-Guillén; Gloria González-Aseguinolaza; Pedro Berraondo; Iñaki F. Trocóniz

Publisher
Springer US
Year
2010
Tongue
English
Weight
364 KB
Volume
27
Category
Article
ISSN
0724-8741

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✍ V. Nigrovic; J. Gaspari; M. Banoub 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 832 KB

Our goal was to develop a pharmacokinetic-pharmacodynamic model that describes the fate of atracurium and its metabolite laudanosine as well as the time course of the neuromuscular block. The model was based on the consideration of mass balance of atracurium and was constructed by postulating an eff