## Abstract RNA interference (RNAi) is a potent mechanism for local silencing of gene expression and can be used to study loss‐of‐function phenotypes in mammalian cells. We used RNAi to knockdown specifically the expression of choline acetyltransferase (ChAT), the enzyme of acetylcholine biosynthes
Gene silencing in adult rat cardiac myocytes in vitro by adenovirus-mediated RNA interference
✍ Scribed by Andreas Rinne; Christoph Littwitz; Marie-Cécile Kienitz; Andreas Gmerek; Leif I. Bösche; Lutz Pott; Kirsten Bender
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 352 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0142-4319
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract To investigate the efficacies and the longevity of RNA interference in nucleus pulposus cells from rat and human, two reporter luciferase plasmids (__Firefly__ and __Renilla__) were used. These plasmids were cotransfected with siRNA targeting __Firefly__ luciferase to the nucleus pulpos
## Abstract Osteopontin (OPN), also called cytokine Eta‐1, expressed in the myocardium co‐incident with heart failure plays an important role in post myocardial infarction (MI) remodeling by promoting collagen synthesis and accumulation. Angiotensin II (Ang II) and inflammatory cytokines are increa