Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging

Decreased proliferation of aging tenocyt

Decreased proliferation of aging tenocytes is associated with down-regulation of cellular senescence-inhibited gene and up-regulation of p27

✍ Wen-Chung Tsai; Hsiang-Ning Chang; Tung-Yang Yu; Cheng-Hsiu Chien; Li-Fen Fu; Fa 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 461 KB

## Abstract Symptomatic tendinopathy tends to be age‐related. However, the molecular mechanisms of ageing and its effects on tenocyte proliferation and cell cycle progression are unknown. We examined tenocytes from Achilles tendons in rats from three age groups (young, 2 months; middle‐aged, 12 mon