Gene regulation in β-sitosterol-mediated stimulation of adipogenesis, glucose uptake, and lipid mobilization in rat primary adipocytes

Combined use of insulin and endothelin-1

Combined use of insulin and endothelin-1 causes decrease of protein expression of β-subunit of insulin receptor, insulin receptor substrate-1, and insulin-stimulated glucose uptake in rat adipocytes

✍ Kuang-Chung Shih; Ching-Fai Kwok; Low-Tone Ho 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 2 views

Previously, we reported that insulin-stimulated glucose uptake (ISGU) can be inhibited by endothelin (ET-1). However, the mechanism by which ET-1 impairs ISGU in adipocytes remains unclear. This study investigated the effects of ET-1 on insulin action in rat adipocytes in order to elucidate the mole