Gene Regulation by Transcription Factors and MicroRNAs

✍ Scribed by Hobert, O.

• Book ID: 118024012
• Publisher: American Association for the Advancement of Science
• Year: 2008
• Tongue: English
• Weight: 169 KB
• Volume: 319
• Category: Article
• ISSN: 0036-8075
• DOI: 10.1126/science.1151651

✦ Synopsis

The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor– and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.