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Gene polymorphisms and pharmacogenetics in rheumatoid arthritis

✍ Scribed by Ignacio Rego-Pérez; Mercedes Fernández-Moreno; Vanessa Carreira-García; Francisco J. Blanco

Book ID
119648530
Publisher
Elsevier Science
Year
2009
Tongue
Spanish
Weight
265 KB
Volume
5
Category
Article
ISSN
2173-5743

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## Abstract ## Objective Recent findings suggest that interferon regulatory factor 5 (IRF‐5) may play a crucial role in several cellular processes, including the transcription of genes for inflammatory cytokines. Two genetic variants of the __IRF5__ gene (rs2004640 in exon 1 and rs2280714 in the 3