## Abstract Some human tumors express known antigens that can be utilized as targets for specific immunotherapy. An absolute requirement for the efficacy of this therapeutic strategy is an adequate expression of the candidate antigen by all cells of the primary and metastatic tumor. To examine the
β¦ LIBER β¦
Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer
β Scribed by Ramila Philip; Elisa Brunette; Bryan Clary; Lydia Kilinski; Deepa Murugesh; Martin Sorich; Josephine Yau; Jane Lebkowski; H. Kim Lyerly; Mohan Philip
- Book ID
- 116167826
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 123 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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Single micrometastatic tumor cells encased in mesenchymal tissues, such as bone marrow (BM), are regarded as suitable targets for adjuvant immunotherapy since they are easily accessible for both immunoglobulins and immune effector cells. However, the antigen profile of such cells, to which antibody