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Gene fusion involvingHMGICis a frequent aberration in uterine leiomyomas

✍ Scribed by N. Mine; K. Kurose; H. Nagai; D. Doi; Y. Ota; K. Yoneyama; H. Konishi; T. Araki; M. Emi

Book ID
106252682
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
105 KB
Volume
46
Category
Article
ISSN
1435-232X

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Cytogenetic aberrations involving chromosome region 12q13-15 occur frequently among benign mesenchymal tumors in humans, e.g., pleomorphic adenomas of the parotid gland, pulmonary chondroid hamartomas, lipomas, or uterine leiomyomas. HMGIC, a gene encoding a protein of the high-mobility group, has b

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## Abstract Human uterine leiomyomas (ULMs) are the most common neoplasms of women. Many genes are dysregulated in ULMs and some of this dysregulation may be due to abnormal expression of micro‐RNAs (miRNAs). In this study, 55 ULMs and matched myometrium were collected from 41 patients for microarr