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Gene Expression Variations in Microsatellite Stable and Unstable Colon Cancer Cells

✍ Scribed by Marjun P. Duldulao; Wendy Lee; Maithao Le; Zhenbin Chen; Wenyan Li; Jinhui Wang; Harry Gao; Haiquing Li; Joseph Kim; Julio Garcia-Aguilar


Book ID
116707731
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
142 KB
Volume
174
Category
Article
ISSN
0022-4804

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## Abstract High‐frequency microsatellite unstable (MSI‐H) colon tumors develop as a consequence of mutations at repetitive sequences in target genes. __TGFBR2__ and __ACVR2__, encoding TGFΞ² superfamily receptors, and the proapoptotic gene __BAX__ are frequent targets for frameshift mutation. We an